Nearly one in three Ghanaians are between the ages of 10 and 24. Many of these young people are at risk or already struggling with the consequences of an unplanned pregnancy or a sexually transmitted infection (STI), including HIV/AIDS. To minimize these risks and secure a healthy future for adolescents, policymakers, journalists, service providers and advocates need solid evidence regarding the sexual and reproductive health needs of Ghanaian youth. This Research in Brief documents what is known about Ghanaian adolescents’ sexual and reproductive health behaviors and needs, with particular emphasis on HIV/AIDS, and points the way toward improving policies and programs.